Our brains make us what we are. How did they get that way? How are they different from other animals' and how are they similar? This course explores the structure and function of the modern human brain and examines the selective pressures that have impacted the evolution of human neuroanatomy and cognition. Frequent comparisons are made with other primate and non-primate species in order to situate an understanding of Homo sapiens within the context of the broader animal kingdom. Additionally, the course delves into the types of methodological approaches used to study these topics and consider the frontiers of new knowledge in this area. The course integrates research and theory from biological anthropology, archaeology, psychology, ethology, and neuroscience. Topics covered include the evolution of large brains in humans and other species; the emergence of specializations for communication, tool use, and culture; social cognition and theory of mind; individual variation and experience-dependent plasticity in the brain; and domestication and self-domestication.